Tutaj masz świeże dane:
http://www.cbc.ca/he...n1-vaccine.html
&& http://www.cbc.ca/he...accine-who.html
"From a WHO point of view, the fact that the findings are not replicated in other countries I think is reassuring for us that this is an outlier, if you like, the unexpected findings that are coming out of Canada," said David Wood, co-ordinator of the quality, safety and standards team of WHO's department of immunization, vaccines and biologicals.
"Most people are still looking at this as some sort of undetected confounding in the data, that for some reason is giving the results that are there."
In an interview from Geneva, Wood was diplomatic. But when pressed, he admitted most experts on the call didn't seem to believe that the unpublished study, based on data from British Columbia, Quebec and Ontario, had found a true link between getting a seasonal flu vaccine and having an increased risk of coming down with a mild case of H1N1 flu.
"Well, yeah," he said. "It's a totally unexpected finding."
"So I think people do then try to think: 'Well, why is this happening? Are there some effects that are just not being detected that are really behind this?' Because it is an unexpected finding. That's the way people tend to think."
Provinces changed flu plans
The work, which, it is said, is being considered for publication by a medical journal, contributed to decisions by most provinces and territories to stagger or delay their seasonal flu shot efforts this fall.
Instead of launching full-fledged seasonal flu vaccine programs in October, most have announced they will offer seasonal shots during the month only to seniors — who aren't currently at high risk from the pandemic H1N1 virus — and residents of long-term-care facilities.
After pandemic vaccination efforts are completed, most of those provinces plan to offer seasonal vaccine more broadly.
A couple of jurisdictions — Quebec and Nunavut — will wait until after they've completed their pandemic vaccination efforts before offering seasonal flu shots. At the other end of the spectrum, New Brunswick is going ahead with its regular seasonal flu shot campaign before offering pandemic flu shots.
Statistical flaws?
The Canadian findings, which are reportedly mirrored in data from Manitoba as well, suggest that people who got a flu shot last fall were twice as likely as people who didn't to contract swine flu. But the association, if it is real, is to mild disease. There is no evidence that people who got seasonal flu shots are more prone to develop severe illness if they catch the new H1N1 virus.
Scientists from the United States, Britain and Australia have looked at their data, but didn't see the same effect. A number of scientists have speculated that the Canadian data may have some built-in confounders — factors that can produce false results.
For instance, if people who get flu shots are also more likely to seek a diagnosis of swine flu if they get sick, that could make it seem like more of them got the illness when in fact what happened is that more of their illnesses were recorded.
But if the Canadian results are due to some statistical flaws or selection biases, no one on the 4½-hour teleconference was able to put a finger on what exactly the problem is, Wood acknowledged.
And he admitted there may not be a satisfactory answer to that puzzle in the foreseeable future.
"It didn't seem very likely that we're going to be able to … suddenly come up with the magic explanation as to why the Canadian data are different to others," Wood said. "In the short term, this is really probably as far as we're going to get."
New studies will likely be needed to get a definitive answer, he said.
More studies needed
Experts say there will need to be prospective studies — following people who get a flu shot forward —rather than the retrospective studies that produced the unusual findings. The evidence from retrospective studies isn't considered as high quality as that garnered from prospective studies.
In the meantime, a summary of the situation will be presented to the WHO's Strategic Advisory Group of Experts on immunization, also known as the SAGE. The group, which meets later this month, makes recommendations for the WHO on vaccination policy.
Wood said he couldn't prejudge what the committee will decide, but said for the moment it doesn't seem like the WHO needs to ask countries to change their vaccination programs for this fall.
"The fact that it's just been seen in Canada at the moment, I don't think that that's going to force global policy changes," he said.
© The Canadian Press, 2009
I teraz możemy sobie porozmawiać na forum.
Aha, ktoś nie wierzył w przenoszenie się świnki ze świnek na ludzi - proszę oto coś
Swine influenza viruses possessing avian genes were first detected in Europe in 1979 (Scholtissek et al., 1983, Virology, 129, 521-523) and continue to circulate in pigs in that region of the world. To characterize the molecular epidemiology of swine influenza viruses currently circulating in Europe, we used dot-blot hybridization and sequence analysis to determine the origin of the genes encoding the nonsurface proteins ("internal" genes) of 10 H1N1 and 11 H3N2 swine influenza viruses isolated in Italy between 1992 and 1995. All of the 126 genes examined were of avian origin; thus the currently circulating H3N2 strains which possess A/Port Chalmers/1/73-like surface glycoproteins appear to be descendants of the reassortant human-avian viruses that emerged between 1983 and 1985 in Italy. Sequence analysis of matrix (M), nonstructural, and nucleoprotein genes, as well as phylogenetic analysis of M gene showed that the H1N1 and H3N2 viruses from the pigs were closely related to recent isolates of the avian-like swine H1N1 influenza strain currently circulating in northern Europe and were distinguishable from the genes of viruses isolated from European swine in 1979. To evaluate the frequency of transmission of swine H1N1 and H3N2 viruses to man, we tested 123 human sera for hemagglutination-inhibiting antibodies against avian and mammalian H1N1 and H3N2 virus strains. Our findings indicate that swine influenza viruses possessing A/Port Chalmers/1/73-like hemagglutinin may have transmitted to approximately 20% of young persons under 20 years of age who had contact with pigs. Thus, H3N2 swine viruses, possibly possessing avian-derived internal genes, may be entering humans more often than was previously thought. We strongly recommend that pigs be regularly monitored as a potential early warning system for detection of future pandemic strains.
A wracając do tematu szczepów H1N1 i H3N2 w szczepionkach
http://www.cdc.gov/h...tion_qa_pub.htm
Will the seasonal flu vaccine also protect against the 2009 H1N1 flu?
The seasonal flu vaccine is not expected to protect against the 2009 H1N1 flu.
Mariush, nie wiem, skąd masz te dane, przytocz źródło -
H1N1 to tylko jeden z podtypów grypy. Ten podtyp jest obecny wśród nas od dawna i zapewne niejeden z nas miał okazję chorować na grypę spowodowaną przez należące do niego wirusy. Rzecz jasna, od lat zawierają go także szczepionki na grypę sezonową, więc mówienie o braku studiów nad tym podtypem jest niedorzeczne.
Niedorzeczne dla mnie jest opowiadanie takich bajek
Użytkownik sechmet edytował ten post 06.10.2009 - 17:26
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